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. 2005 Oct 3;93(7):825-33.
doi: 10.1038/sj.bjc.6602769.

Systematic review of the relationship between family history and lung cancer risk

A Matakidou  1 , T Eisen, R S Houlston
Affiliations

Systematic review of the relationship between family history and lung cancer risk

A Matakidou et al. Br J Cancer. .

Abstract

We performed a systematic review of 28 case-control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case-control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed.

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Figures

Figure 1
Figure 1
Forrest plot of Relative risks (RR) of lung cancer in the case–control and cohort studies examining the relationship between family history and lung cancer risk, CI=confidence interval.
Figure 2
Figure 2
Forrest plot of familial lung cancer risks in never-smokers. RR=relative risks, CI= confidence interval.
Figure 3
Figure 3
Forrest plot of Relative risks (RR) of lung cancer associated with history of lung cancer in a spouse. CI=confidence interval.
See this image and copyright information in PMC

References

    1. Ahlbom A, Lichtenstein P, Malmstrom H, Feychting M, Hemminki K, Pedersen NL (1997) Cancer in twins: genetic and nongenetic familial risk factors. J Natl Cancer Inst 89: 287–293 - PubMed
    1. Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson MW (2004) A major lung cancer susceptibility locus maps to chromosome 6q23–25. Am J Hum Genet 75: 460–474 - PMC - PubMed
    1. Bradburn MJ, Deeks JJ, Altman DG (1999) Metan-an alternative meta-analysis command. In Stata Technical Bulletin, Vol. 8. Stata Corporation
    1. Braun MM, Ahlbom A, Floderus B, Brinton LA, Hoover RN (1995a) Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden). Cancer Causes Control 6: 519–524 - PubMed
    1. Braun MM, Caporaso NE, Page WF, Hoover RN (1994) Genetic component of lung cancer: cohort study of twins. Lancet 344: 440–443 - PubMed

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