[Free-Wilson analysis of the inhibitory effect of 4-substituted benzamidines on thrombin, plasmin and trypsin (author's transl)]

Abstract

Using the Fujita-Ban model, the authors studied the quantitative structure-inhibitory activity relationships of a series of 4-amidinophenyl compounds with regard to thrombin, plasmin and trypsin. A satisfactory specification of the inhibitory activities was obtained from activity increments of molecular segments.