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Case Reports
. 2005 Oct;64(10):1519-20.
doi: 10.1136/ard.2004.032821.

Autoimmune hepatitis associated with infliximab in a patient with psoriatic arthritis

V Germano, A Picchianti Diamanti, G Baccano, E Natale, A Onetti Muda, R Priori, G Valesini
Case Reports

Autoimmune hepatitis associated with infliximab in a patient with psoriatic arthritis

V Germano et al. Ann Rheum Dis. 2005 Oct.
No abstract available

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Figures

Figure 1
Figure 1
(A) A liver biopsy revealed intense and diffuse portal lymphoplasmacytic, granulocytic inflammatory infiltration and severe interface hepatitis; Diffuse macro-microvesicular steatosis (over 60% hepatocytes), intranuclear glycogen accumulation, and hyaline degeneration of hepatocytes (Mallory bodies) were also noted. Mild periportal fibrosis was evident with formation of incomplete septa and perisinusoidal and perivenular fibrosis. (B) Lobular evidence of confluent necrosis and inflammatory infiltrates.
Figure 2
Figure 2
Chronological relationship between transaminasitis and infliximab in the patient. AST, aspartate aminotransferase; ALT, alanine aminotransferase; T, time in weeks; MTX, methotrexate; CyA, ciclosporin A; ANA, antinuclear antibodies; ASMA, anti-smooth muscle antibodies; a-DNA, anti-DNA antibodies.
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