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. 2005 Nov 15;15(22):4898-906.
doi: 10.1016/j.bmcl.2005.08.034.

Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators

George P Lahm  1 , Thomas P Selby, John H Freudenberger, Thomas M Stevenson, Brian J Myers, Gilles Seburyamo, Ben K Smith, Lindsey Flexner, Christopher E Clark, Daniel Cordova
Affiliations

Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators

George P Lahm et al. Bioorg Med Chem Lett. .

Abstract

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.

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