Comment
doi: 10.1016/j.molcel.2005.08.029.
Yos9p: a sweet-toothed bouncer of the secretory pathway
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- PMID: 16168366
- DOI: 10.1016/j.molcel.2005.08.029
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Comment
Yos9p: a sweet-toothed bouncer of the secretory pathway
Mol Cell.
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Free article
Abstract
In this issue of Molecular Cell, Bhamidipati et al., (2005) and Kim et al., (2005), and Szathmary et al. (2005), and demonstrate that Yos9p selectively binds to aberrant glycoproteins in the endoplasmic reticulum (ER) and targets them for destruction through the ER-associated protein degradation pathway.
Comment on
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Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.Mol Cell. 2005 Sep 16;19(6):741-51. doi: 10.1016/j.molcel.2005.07.027. Mol Cell. 2005. PMID: 16168370
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Yos9p detects and targets misfolded glycoproteins for ER-associated degradation.Mol Cell. 2005 Sep 16;19(6):753-64. doi: 10.1016/j.molcel.2005.08.010. Mol Cell. 2005. PMID: 16168371
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Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.Mol Cell. 2005 Sep 16;19(6):765-75. doi: 10.1016/j.molcel.2005.08.015. Mol Cell. 2005. PMID: 16168372
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