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. 2005 Dec 1;15(23):5257-61.
doi: 10.1016/j.bmcl.2005.08.050. Epub 2005 Sep 15.

2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV

Curt D Haffner  1 , Darryl L McDougald, Steven M Reister, Brian D Thompson, Christopher Conlee, Jing Fang, Jonathan Bass, James M Lenhard, Dallas Croom, Melissa B Secosky-Chang, Thaddeus Tomaszek, Donavon McConn, Kevin Wells-Knecht, Paul R Johnson
Affiliations

2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV

Curt D Haffner et al. Bioorg Med Chem Lett. .

Abstract

We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.

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