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. 2005 Sep;8(3):171-2.
doi: 10.1016/j.ccr.2005.08.007.

A new mouse model of pancreatic cancer: PTEN gets its Akt together

Anirban Maitra  1 , Ralph H Hruban
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Free article

A new mouse model of pancreatic cancer: PTEN gets its Akt together

Anirban Maitra et al. Cancer Cell. 2005 Sep.
Free article

Abstract

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a negative regulator of the oncogenic PI3-K/Akt signaling pathway. Loss-of-function mutations of PTEN are seen in several human solid cancers. A murine model of conditional Pten inactivation in the pancreas is described that leads to acquisition of a profound metaplastic ductal phenotype accompanied by loss of differentiated acinar units. Evidence is presented for a centroacinar cell origin of the metaplastic "neoductules." These mice also develop invasive pancreatic adenocarcinomas at a low frequency, and provide a unique in vivo platform for exploring the role of PI3-K/Akt signaling in pancreatic neoplasia.

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