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Review
. 2005 Sep;23(3):241-2.
doi: 10.1016/j.immuni.2005.08.011.

Identification of early cellular immune factors regulating growth of malaria parasites in humans

Michael F Good
Free article
Review

Identification of early cellular immune factors regulating growth of malaria parasites in humans

Michael F Good. Immunity. 2005 Sep.
Free article

Abstract

In many host-parasite systems, regulatory T cells (CD4+, CD25+, FOXP3+) have been shown to modulate cellular immunity and pathology. In this issue of Immunity, Walther et al. have now shown that following experimental malaria infection of human volunteers, enhanced TGF-beta and T reg responses are associated with a faster parasite growth rate. The study demonstrates that regulation of cellular immunity must be addressed if we are to develop successful interventions.

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