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Randomized Controlled Trial
. 2005 Sep-Oct;20(5):450-63.
doi: 10.1097/00001199-200509000-00006.

Neurobehavioral effects of amantadine after pediatric traumatic brain injury: a preliminary report

Sue R Beers  1 , Anna Skold, Clifton Edward Dixon, Philip David Adelson
Affiliations
Randomized Controlled Trial

Neurobehavioral effects of amantadine after pediatric traumatic brain injury: a preliminary report

Sue R Beers et al. J Head Trauma Rehabil. 2005 Sep-Oct.

Abstract

Objective: To investigate the safety and efficacy of a dopamine agonist, amantadine hydrochloride (AMH), in the treatment of neurobehavioral sequelae of pediatric TBI.

Procedures: Age- and severity-matched traumatic brain injury groups, randomized to AMH (n = 17) or usual care (n = 10), completed behavior scales and neuropsychological tests. Effect sizes measured the treatment effect within subjects and between groups. Side effects were tracked over the 12-week study course.

Results: Behavior improved in the AMH group, but only those 2 years or fewer postinjury showed a treatment effect on cognitive tests.

Conclusions: After traumatic brain injury, a 12-week course of AMH was safe and, according to parent report, improved behavior. AMH may have the potential to improve cognition in more recently injured children.

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