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. 2005 Oct;37(10):1072-81.
doi: 10.1038/ng1642. Epub 2005 Sep 18.

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L Harvey  1 , R Sathish Srinivasan, Miriam E Dillard, Nicole C Johnson, Marlys H Witte, Kelli Boyd, Mark W Sleeman, Guillermo Oliver
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Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

Natasha L Harvey et al. Nat Genet. 2005 Oct.

Abstract

Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.

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  • Lymph makes you fat.
    Schneider M, Conway EM, Carmeliet P. Schneider M, et al. Nat Genet. 2005 Oct;37(10):1023-4. doi: 10.1038/ng1005-1023. Nat Genet. 2005. PMID: 16195715 No abstract available.

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