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Review
. 2005 Sep 27;102(39):13719-20.
doi: 10.1073/pnas.0507068102. Epub 2005 Sep 19.

Holding the reins on myosin V

Adrian O Olivares  1 , Enrique M De La Cruz
Affiliations
Review

Holding the reins on myosin V

Adrian O Olivares et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Effects of backward loads on the ATPase cycle and processive motility of myosin V accounting for the observations of Purcell et al. (9). (A) Strong actin-binding myosin heads are colored black, and weak actin-binding heads are colored blue. Purcell et al. provide evidence for an additional ADP-bound actomyosin state (AM.D*, yellow head) that is populated under backward loads and may represent a transiently populated ATPase cycle biochemical intermediate. (B) Simplified model of coordinated myosin V processive stepping. Purcell et al. demonstrate that a backward load, thought to represent the force on the leading head, slows ADP release from myosin V. A stepping intermediate with the trailing head strongly bound to actin and the leading head, under backward load, bound to actin and ADP is likely to be populated (17).
See this image and copyright information in PMC

Comment on

References

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