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. 2005 Nov;273(1):35-8.
doi: 10.1007/s00404-005-0739-x. Epub 2005 Oct 28.

New approach of the treatment of von Willebrand's disease during pregnancy

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New approach of the treatment of von Willebrand's disease during pregnancy

Miroslava Gojnic et al. Arch Gynecol Obstet. 2005 Nov.

Abstract

Aim: The aim of the study was to analyze the effectiveness of the application of DDAVP (desmopressin) and Hemate P with cryoprecipitate pre- and postpartum in patients with von Willebrand disease.

Methods: We monitored 32 patients with von Willebrand disease during the study period 1993-2003. DDAVP was applied in the 36th/37th week of gestation and cryoprecipitate and fresh frozen plasma were applied 1 day before and 3 days after delivery. DDAVP treatment continued for 4 weeks. Factor VIII (Hemate P) at the day of delivery

Results: No complications occurred in the studied population.

Conclusion: Precipitation of DDAVP, Hemate P, and cryoprecipitate may help in the treatment of pregnant women with von Willebrand disease.

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