Review
doi: 10.1016/j.ijmm.2005.06.007.
Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells
Affiliations
- PMID: 16173500
- DOI: 10.1016/j.ijmm.2005.06.007
Item in Clipboard
Review
Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells
Int J Med Microbiol.
2005 Sep.
Abstract
Helicobacter pylori is a microbial pathogen that colonises the stomach of more than half of the world's human population. H. pylori infection can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. A prominent feature of H. pylori is the presence of a pathogenicity island (PAI) which encodes a type IV secretion system (T4SS). This review focuses on the processes of how H. pylori induces PAI-dependent epithelial cell signalling that might be of importance in gastric inflammation and the pathogenesis of neoplasia.
Similar articles
-
Orchestration of aberrant epithelial signaling by Helicobacter pylori CagA.Sci STKE. 2005 Mar 29;2005(277):pe14. doi: 10.1126/stke.2772005pe14. Sci STKE. 2005. PMID: 15798102 Review.
-
[The type IV secretion system encoded by the cag PAI of Helicobacter pylori].Wei Sheng Wu Xue Bao. 2007 Aug;47(4):743-5. Wei Sheng Wu Xue Bao. 2007. PMID: 17944386 Review. Chinese.
-
Helicobacter pylori-host cell interactions mediated by type IV secretion.Cell Microbiol. 2005 Jul;7(7):911-9. doi: 10.1111/j.1462-5822.2005.00541.x. Cell Microbiol. 2005. PMID: 15953024 Review.
-
Helicobacter pylori-induced gastric inflammation and gastric cancer.Cancer Lett. 2014 Apr 10;345(2):196-202. doi: 10.1016/j.canlet.2013.08.016. Epub 2013 Aug 24. Cancer Lett. 2014. PMID: 23981572 Review.
-
Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus.FEBS J. 2011 Apr;278(8):1203-12. doi: 10.1111/j.1742-4658.2011.08036.x. Epub 2011 Feb 25. FEBS J. 2011. PMID: 21352490 Review.
Cited by
-
Pathogenesis of Helicobacter pylori infection.Clin Microbiol Rev. 2006 Jul;19(3):449-90. doi: 10.1128/CMR.00054-05. Clin Microbiol Rev. 2006. PMID: 16847081 Free PMC article. Review.
-
Characterization of Lactobacillus salivarius strains B37 and B60 capable of inhibiting IL-8 production in Helicobacter pylori-stimulated gastric epithelial cells.BMC Microbiol. 2016 Oct 18;16(1):242. doi: 10.1186/s12866-016-0861-x. BMC Microbiol. 2016. PMID: 27756217 Free PMC article.
-
Inflammation and Gastric Cancer.Diseases. 2022 Jun 22;10(3):35. doi: 10.3390/diseases10030035. Diseases. 2022. PMID: 35892729 Free PMC article. Review.
-
Impact of cagPAI and T4SS on the inflammatory response of human neutrophils to Helicobacter pylori infection.PLoS One. 2013 Jun 3;8(6):e64623. doi: 10.1371/journal.pone.0064623. Print 2014. PLoS One. 2013. PMID: 23755130 Free PMC article.
-
Outer Membrane Vesicles Secreted by Helicobacter pylori Transmitting Gastric Pathogenic Virulence Factors.ACS Omega. 2021 Dec 28;7(1):240-258. doi: 10.1021/acsomega.1c04549. eCollection 2022 Jan 11. ACS Omega. 2021. PMID: 35036696 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
