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. 2005 Sep 28;127(38):13154-5.
doi: 10.1021/ja054549f.

Highly regioselective arylation of sp3 C-H bonds catalyzed by palladium acetate

Vladimir G Zaitsev  1 , Dmitry Shabashov, Olafs Daugulis
Affiliations

Highly regioselective arylation of sp3 C-H bonds catalyzed by palladium acetate

Vladimir G Zaitsev et al. J Am Chem Soc. .

Abstract

A new palladium-catalyzed arylation process based on C-H activation has been developed. The utilization of pyridine-containing directing groups allows the beta-arylation of carboxylic acid derivatives and gamma-arylation of amine derivatives. Both primary and secondary sp3 C-H bonds, as well as sp2 C-H bonds, are reactive.

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