Deception in research on the placebo effect
- PMID: 16173830
- PMCID: PMC1198039
- DOI: 10.1371/journal.pmed.0020262
Deception in research on the placebo effect
Abstract
A common feature of research investigating the placebo effect is deception of research participants about the nature of the research. Miller and colleagues examine the ethical issues surrounding such deception.
Conflict of interest statement
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Comment in
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Placebo: physician, heal thyself.PLoS Med. 2005 Nov;2(11):e388. doi: 10.1371/journal.pmed.0020388. Epub 2005 Nov 29. PLoS Med. 2005. PMID: 16288561 Free PMC article. No abstract available.
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References
-
- Kleinman A, Guess HA, Wilentz JS. In: An overview. Guess HA, Kleinman A, Kusek JW, Engel LW, editors. London: BMJ; 2002. pp. 1–32. The science of the placebo: Towards an interdisciplinary research agenda.
-
- Harrington A, editor. The placebo effect: An interdisciplinary exploration. Cambridge (Massachusetts): Harvard University Press; 1997. 272 pp.
-
- Kirsch I. Response expectancy as a determinant of experience and behavior. Am Psychol. 1985;40:1189–1202.
-
- Pollo A, Amanzio M, Arslanian A, Casadio C, Maggi G, et al. Response expectancies in placebo analgesia and their clinical relevance. Pain. 2001;93:77–84. - PubMed
-
- Stewart-Williams S, Podd J. The placebo effect: Dissolving the expectancy versus conditioning debate. Psychol Bull. 2004;130:324–340. - PubMed
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