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Review
. 2005 Oct;7(5):382-8.
doi: 10.1007/s11926-005-0026-7.

Chemokines: their role in rheumatoid arthritis

Clarissa E Vergunst  1 , Paul P Tak
Affiliations
Review

Chemokines: their role in rheumatoid arthritis

Clarissa E Vergunst et al. Curr Rheumatol Rep. 2005 Oct.

Abstract

Chemokines are small proteins that can act on cells that express matching receptors. They are best known for their role in migration of cells, especially immune cells. Chemokine/chemokine-receptor pairs are often functionally categorized into three groups: inflammatory, homeostatic, and angiogenic/angiostatic, although functions sometimes overlap. Interfering with the interaction between chemokines and their receptors is currently under investigation as a therapeutic strategy in rheumatoid arthritis.

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