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Review
. 2005 Oct:20:357-65.
doi: 10.1152/physiol.00030.2005.

Proglucagon-derived peptides: mechanisms of action and therapeutic potential

Elaine M Sinclair  1 , Daniel J Drucker
Affiliations
Free article
Review

Proglucagon-derived peptides: mechanisms of action and therapeutic potential

Elaine M Sinclair et al. Physiology (Bethesda). 2005 Oct.
Free article

Abstract

Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic actions of the proglucagon-derived peptides, with an emphasis on clinical relevance of the peptides for the treatment of human disease.

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