Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Oct;5(10):786-95.
doi: 10.1038/nrc1713.

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

Rosa A Cardone  1 , Valeria Casavola, Stephan J Reshkin
Affiliations
Review

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

Rosa A Cardone et al. Nat Rev Cancer. 2005 Oct.

Abstract

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?

PubMed Disclaimer

Publication types

LinkOut - more resources