Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2005 Sep-Oct;5(5):169-70.
doi: 10.1111/j.1535-7511.2005.00053.x.

Cytokines: a link between fever and seizures

Andrey M Mazarati
Comment

Cytokines: a link between fever and seizures

Andrey M Mazarati. Epilepsy Curr. 2005 Sep-Oct.
No abstract available

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Cytokines are a concurrent component of fever and seizures Exogenous pyrogenic factors (e.g., lipopolysaccharide) or hyperthermia lead to fever by acting at Toll-like receptors and through the induction of cytokines. Cytokines facilitate seizures through phosphorylation of the NR2A/B subunit of N-methyl-d-aspartate receptors and via prostaglandin E2, an endogenous cytokine-induced pyrogen. Seizures, in turn, lead to the expression of cytokines in the brain, thus forming a vicious circle that contributes to seizure progression. PGE2, Prostaglandin E2; LPS, lipopolysaccharide.
See this image and copyright information in PMC

Comment on

References

    1. Heida JG, Boisse L, Pittman QJ. Lipopolysaccharide-induced febrile convulsions in the rat: Short-term sequelae. Epilepsia. 2004;45:1317–1329. - PubMed
    1. Sayyah M, Javad-Pour M, Ghazi-Khansari M. The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: Involvement of proinflammatory factors nitric oxide and prostaglandins. Neuroscience. 2003;122:1073–1080. - PubMed
    1. Roth J, de Souza GEP. Fever-induction pathways: evidence from responses to systemic or local cytokine formation. Braz J Med Biol Res. 2001;34:301–314. - PubMed
    1. Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: Some concepts have changed. J Endotoxin Res. 2004;10:301–222. - PubMed
    1. Bender RA, Dube C, Baram TZ. Febrile seizures and mechanisms of epileptogenesis: insights from an animal model. Adv Exp Med Biol. 2004;548:213–225. - PMC - PubMed