Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping
- PMID: 16175512
- PMCID: PMC1275615
- DOI: 10.1086/491658
Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping
Abstract
The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach.
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Web Resources
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- Statistical Source, http://www.statisticalsource.com/software/CZGL.sas (for SAS program/macro for the simulation study)
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