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. 2005 Oct;77(4):661-9.
doi: 10.1086/491658. Epub 2005 Aug 15.

Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping

Zehua Chen  1 , Gang Zheng, Kaushik Ghosh, Zhaohai Li
Affiliations

Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping

Zehua Chen et al. Am J Hum Genet. 2005 Oct.

Abstract

The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach.

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Figures

Figure 1
Figure 1
Power curves of test 3 with the three selection approaches, ERS, TS-II, and TS-I. a, k=10. b, k=20.
See this image and copyright information in PMC

References

Web Resources

    1. Statistical Source, http://www.statisticalsource.com/software/CZGL.sas (for SAS program/macro for the simulation study)

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