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Review
. 2005 Oct;142(1):1-11.
doi: 10.1111/j.1365-2249.2005.02834.x.

Clinical uses of intravenous immunoglobulin

S Jolles  1 , W A C Sewell, S A Misbah
Affiliations
Review

Clinical uses of intravenous immunoglobulin

S Jolles et al. Clin Exp Immunol. 2005 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Immunomodulatory actions of intravenous immunoglobulin. Intravenous immunoglobulin (IVIG), may for the purposes of understanding, be thought of as four separate components: (1) actions mediated by the variable regions F(ab′)2, (2) actions of Fc region on a range of Fc receptors (FcR), (3) actions mediated by complement binding within the Fc fragment and (4) immunomodulatory substances other than antibody in the IVIG preparations. It should be remembered that not all the potential mechanisms of action fit perfectly into the groupings and that several mechanisms may act concurrently (TCR, T cell receptor; ADCC, antibody dependent cellular cytotoxicity; DC, dendritic cell).
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