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. 2005 Oct;142(1):167-71.
doi: 10.1111/j.1365-2249.2005.02891.x.

Association between atopy and recurrent vaginal candidiasis

N A Neves  1 , L P Carvalho, M A M De Oliveira, P C Giraldo, O Bacellar, A A Cruz, E M Carvalho
Affiliations

Association between atopy and recurrent vaginal candidiasis

N A Neves et al. Clin Exp Immunol. 2005 Oct.

Abstract

To determine whether there is an association between atopy and recurrent vaginal candidiasis (RVC) and to evaluate the type-2 immune response in patients with RVC. Evaluation of immediate hypersensitivity skin tests to aeroallergens, measurement of total IgE and Candida albicans specific IgE and levels of IL-5 in 44 women with RVC and 26 with sporadic vaginal candidiasis (SVC). Statistical analyses were performed by Mann-Whitney test and chi(2) test with Yates correction. History of atopy (68%) and positive skin test (42%) were higher (P < 0.05) in RVC than in patients with SVC. No significant difference was found in total IgE, C. albicans specific IgE and IL-5 levels. There was a strong association between atopy and RVC, but type-2 immune response to C. albicans antigen was absent or similar in the two groups of patients.

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Figures

Fig. 1
Fig. 1
(a) Levels of total IgE in patients with recurrent vaginal candidiasis (RVC) and sporadic vaginal candidiasis (SVC); P = 0·3012. (b) Levels of Candida-specific IgE in patients with recurrent vaginal candidiasis (RVC) and sporadic vaginal candidiais (SVC); P = 0·0721.
Fig. 2
Fig. 2
Levels of IL-5 in cultures stimulated with C. albicans and PHA in patients with recurrent vaginal candidiasis (RVC) and sporadic vaginal candidiasis (SVC); P = 0·7039.
See this image and copyright information in PMC

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References

    1. Anyon CP, Desmond FB, Esatcott DF. A study of Candida in one thousand and seven women. NZ Med J. 1971;73:9–12. - PubMed
    1. Giraldo P, Von Nowaskonski A, Gomes FA, Linhares I, Neves NA, Witkin SS. Vaginal colonization by Candida in asymptomatic women with and without a history of recurrent vulvovaginal candidiasis. Obstet Gynecol. 2000;95:413–6. - PubMed
    1. Hurly R. Recurrent candida infection. Clin Obstet Gynecol. 1981;8:209–13. - PubMed
    1. Corrigan EM, Clancy RL, Dunkley ML, Eyers FM, Beagley KW. Cellular immunity in recurrent vulvovaginal candidiasis. Clin Exp Immunol. 1998;111:574–8. - PMC - PubMed
    1. Witkin SS. Inhibition of Candida-induced lymphocyte proliferation by antibody to Candida albicans. Obstet Gynecol. 1986;68:696–9. - PubMed

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