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Review
. 1992 Jun;11(2):189-94.
doi: 10.1007/BF02207955.

The role of pregnancy in the course and aetiology of rheumatoid arthritis

J A Da Silva  1 , T D Spector
Affiliations
Review

The role of pregnancy in the course and aetiology of rheumatoid arthritis

J A Da Silva et al. Clin Rheumatol. 1992 Jun.

Abstract

The aetiology of rheumatoid arthritis (RA) is unknown, although being female is generally recognized as the most important independent risk factor, the disease being 2 to 3 times more frequent in females than in males. The dramatic effect of pregnancy in rheumatoid arthritis has been documented for over 50 years. This review examines the evidence and possible mechanisms by which pregnancy modifies the disease process and may alter predisposition to the development of RA in later life.

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