Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Sep 23;122(6):825-7.
doi: 10.1016/j.cell.2005.09.001.

CDKs give Cdc6 a license to drive into S phase

Nagi G Ayad  1
Affiliations
Free article
Review

CDKs give Cdc6 a license to drive into S phase

Nagi G Ayad. Cell. .
Free article

Abstract

The accumulation of Cdc6 promotes the initiation of DNA replication. In this issue of Cell, Mailand and Diffley (2005) show that phosphorylation of Cdc6 by cyclin-dependent kinases prevents its destruction by the anaphase promoting complex (APC). This simple mechanism explains how the APC simultaneously spares Cdc6 while targeting for destruction suppressors of DNA replication during the transition from quiescence to cell cycle reentry.

PubMed Disclaimer

Comment on

LinkOut - more resources