Comment
doi: 10.1016/j.cell.2005.09.002.
Chipping away at the embryonic stem cell network
Affiliations
- PMID: 16179251
- DOI: 10.1016/j.cell.2005.09.002
Item in Clipboard
Comment
Chipping away at the embryonic stem cell network
Cell.
.
Free article
Abstract
Critical transcription factors, notably OCT4, SOX2, and NANOG, are necessary to maintain self-renewal and pluripotency, two properties characteristic of embryonic stem (ES) cells. By analyzing the genome-wide localization of these factors at promoter regions in human ES cells, Boyer et al. (2005) demonstrate frequent promoter co-occupancy at numerous target genes. As they discuss in this issue of Cell, their findings indicate the presence of a complex network of autoregulatory and feedforward loops in human ES cells.
Comment on
-
Core transcriptional regulatory circuitry in human embryonic stem cells.Cell. 2005 Sep 23;122(6):947-56. doi: 10.1016/j.cell.2005.08.020. Cell. 2005. PMID: 16153702 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
