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. 2005 Oct;153(4):815-20.
doi: 10.1111/j.1365-2133.2005.06776.x.

First case series on the use of imiquimod for morphoea

M Dytoc  1 , P T Ting, J Man, D Sawyer, L Fiorillo
Affiliations

First case series on the use of imiquimod for morphoea

M Dytoc et al. Br J Dermatol. 2005 Oct.

Abstract

Background: Morphoea is characterized by fibrosis, which is mediated by cytokines including transforming growth factor (TGF)-beta.

Objective: Our objective was to use imiquimod 5% cream (Aldara), an inducer of interferon-gamma, known to inhibit TGF-beta, to treat morphoea.

Methods: Patients with morphoea were treated with imiquimod and evaluated during their follow-up visits to 6 months.

Results: The dyspigmentation, induration and erythema of 12 patients with morphoea lesions improved. The histology of the skin also showed a decrease in dermal thickness.

Conclusion: This is the first case series describing the successful application of imiquimod in the management of morphoea.

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