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. 1992 Jul;117(1):94-6.
doi: 10.1016/0014-4886(92)90116-8.

Amitriptyline produces analgesia in the formalin pain test

J Acton  1 , J E McKenna, R Melzack
Affiliations

Amitriptyline produces analgesia in the formalin pain test

J Acton et al. Exp Neurol. 1992 Jul.

Abstract

A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans. Since the analgesic effect was produced by a single dose, which is insufficient to produce an antidepressant effect, these results indicate that amitriptyline has analgesic properties that are independent of its antidepressant properties.

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