Review
Probing the onset and regulation of erythroid cell-specific gene expression
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- PMID: 16184297
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Review
Probing the onset and regulation of erythroid cell-specific gene expression
Mt Sinai J Med.
2005 Sep.
Abstract
Cell-restricted transcriptional modulators play a crucial role in the process of selective gene regulation during hematopoiesis. Erythroid Kruppel-like factor (EKLF; KLF1) is a transcription factor, originally identified in this laboratory, which plays a crucial role as a transcriptional activator at the adult beta-globin locus. This review will describe a subset of experiments and approaches related to deciphering its mechanism of action and the means by which it itself is induced.
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