Probing the onset and regulation of erythroid cell-specific gene expression

Abstract

Cell-restricted transcriptional modulators play a crucial role in the process of selective gene regulation during hematopoiesis. Erythroid Kruppel-like factor (EKLF; KLF1) is a transcription factor, originally identified in this laboratory, which plays a crucial role as a transcriptional activator at the adult beta-globin locus. This review will describe a subset of experiments and approaches related to deciphering its mechanism of action and the means by which it itself is induced.