Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 May;83(5):495-8.
doi: 10.1111/j.1349-7006.1992.tb01955.x.

Quantitation of gastric intestinal metaplasia by morphometry in Japanese patients

C A Rubio  1 , T Hirota, M Itabashi, S Hirohashi, Y Kato
Affiliations

Quantitation of gastric intestinal metaplasia by morphometry in Japanese patients

C A Rubio et al. Jpn J Cancer Res. 1992 May.

Abstract

With the aid of an image processor, the length of the intestinal metaplasia (IM) was recorded in 33 gastrectomy specimens (23 with early gastric cancer and 10 with gastric peptic ulcer). A total of 1917 sections were analyzed. The length of the areas with IM and the total length of the muscularis mucosa were measured in individual sections. The resulting ratio (length of IM/length of muscularis mucosa) was noted as the intestinal metaplasia index (IMI), as an expression of the extension of IM in the specimens. The IMI was influenced by the age of the patient and by the histologic type of the tumor: a higher IMI was found among older patients and among patients with adenocarcinoma of intestinal type. A comparison with a similar study done in gastrectomy specimens from Swedish patients indicates that despite the latter group being older, and the tumors being more advanced, the IM was much more extended in the gastric mucosa of the Japanese patients with gastric adenocarcinomas of intestinal type. From the results it is suggested that extended IM in the gastric mucosa may have some bearing on the histogenesis of gastric carcinomas, particularly adenocarcinomas of intestinal type.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. ) Muir , C.Waterhouse , J.Mack , T.Powell , J. and Whelan , S.Cancer Incidence in Five Continents , pp. 454 – 455 , 618 – 619 ( 1987. ). International Agency for Research on Cancer; , Lyon .
    1. ) Barry , M. and Buick , M. K.Pathology and cytology of gastric cancer . In “ Management of Gastric Cancer ,” ed. Sugarbaker P. H. , pp. 17 – 39 ( 1991. ). Kluwer Academic Publishers; , Boston . - PubMed
    1. ) Correa , P. , Cuello , C. and Haenszel W.Epidemiologic pathology of precurson lesions and pathogenesis of gastric carcinoma in Colombia . In “ Gastric Cancer, Etiology and Pathogenesis ,” ed. Pfeiffer C. J. , pp. 112 – 127 ( 1979. ). Gerhard Witzstrock Publishing House; , New York .
    1. ) Sipponen , P. , Kekki , M. and Siurala , M.Age‐related trends of gastritis and intestinal metaplasia in gastric carcinoma patients and in control representing the population at large . Br. J. Cancer , 49 , 521 – 530 ( 1984. ). - PMC - PubMed
    1. ) Järvi , O. and Lauren , P.On the role of heterotopias of the intestinal epithelium in the pathogenesis of gastric cancer . Acta Pathol. Microbiol Scand. , 29 , 26 – 43 ( 1951. ). - PubMed

Publication types

LinkOut - more resources