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Review
. 2005 Oct;50(10):1836-8.
doi: 10.1007/s10620-005-2947-4.

Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation

Scott M Suchin  1 , David C Wolf, Young Lee, Gita Ramaswamy, Patricia A Sheiner, Marcelo Facciuto, Michael R Marvin, Leona Kim-Schluger, Edward Lebovics
Affiliations
Review

Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation

Scott M Suchin et al. Dig Dis Sci. 2005 Oct.

Abstract

We report the case of a 22-year-old man who developed fulminant hepatic failure 3 days after an intentional acetaminophen overdose. The patient had a history of a seizure disorder for which he was taking phenytoin. The acetaminophen level at presentation was in the "nontoxic" range. Emergent liver transplantation was performed 4 days after the ingestion. This is the first reported case of successful liver transplantation for acetaminophen-induced fulminant hepatic failure in the setting of phenytoin therapy.

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