Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Oct;60(4):418-22.
doi: 10.1111/j.1365-2125.2005.02448.x.

Allele and genotype frequencies of CYP2C9 in a Korean population

Jung-Woo Bae  1 , Hyun-Kyung Kim, Ji-Hong Kim, Sang-In Yang, Mi-Jeong Kim, Choon-Gon Jang, Young-Seo Park, Seok-Yong Lee
Affiliations

Allele and genotype frequencies of CYP2C9 in a Korean population

Jung-Woo Bae et al. Br J Clin Pharmacol. 2005 Oct.

Abstract

Aims: To determine the frequencies of the variant alleles and the genotypes of CYP2C9 in a Korean population.

Methods: Three hundred and fifty-eight healthy Korean subjects were studied. CYP2C9 alleles were detected by polymerase chain reaction-restriction fragment length polymorphism assays and direct sequencing assays.

Results: The allele frequencies were 0.934 for CYP2C9*1, 0.060 for CYP2C9*3 and 0.006 for CYP2C9*13. The CYP2C9*2,*4,*5 and *11 alleles were not detected. The frequencies of the CYP2C9*1/*1, *1/*3 and *1/*13 genotypes were 0.869, 0.120 and 0.011, respectively.

Conclusion: The frequency of the CYP2C9*3 allele in the Korean population studied was significantly higher than reported elsewhere, and a novel allele, CYP2C9*13, was found at a frequency of 0.006 (95% confidence interval 0, 0.012). Only three genotypes of CYP2C9, CYP2C9*1/*1,*1/*3 and *1/*13 were observed in this Korean population.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Miners JO, Birkett DJ. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol. 1998;45:525–38. - PMC - PubMed
    1. Schwarz UI. Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Invest. 2003;33(Suppl. 2):23–30. - PubMed
    1. Ingelman-Sundberg M, Daly AK, Nebe DW, editors. [26 December 2004]. Human Cytochrome P450 (CYP) Allele Nomenclature Committee Web Site. Available from: http://www.imm.ki.se/CYPalleles/cyp2c9.htm.
    1. Si D, Guo Y, Zhang Y, Yang L, Zhou H, Zhong D. Identification of a novel variant CYP2C9 allele in Chinese. Pharmacogenetics. 2004;14:465–9. - PubMed
    1. Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet. 1999;353:717–9. - PubMed

Substances