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Comment
. 2005 Oct 4;102(40):14125-6.
doi: 10.1073/pnas.0506755102. Epub 2005 Sep 27.

Imaging input and output dynamics of neocortical networks in vivo: exciting times ahead

Amiram Grinvald  1
Affiliations
Comment

Imaging input and output dynamics of neocortical networks in vivo: exciting times ahead

Amiram Grinvald. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
The spatiotemporal capabilities of available tools for studying neocortical structure and function. (A) These are depicted by the colored rectangles. Optical imaging (red) covers almost the entire area, and Kerr et al. (1) established a corner stone here. Multiphoton calcium imaging currently occupies the lower two-thirds of the optical imaging “territory.”(B) Side projection of a two-photon image of OGB-1 loaded cells in the neocortex showing neurons (green) and astrocytes (yellow). (C) Higher magnification area of stained cell. (D) Pseudocolored representation of single cells shown in B depicting the fraction of up-states in which single neurons were active during a 90-s period (color scale). (E) Ongoing calcium transient from the neuropil; the OEG fluctuations (red) correlate with electrical ECoG signals (black). (F) Simultaneous calcium transients from the neuropil; the input (red) and the output from an identified neuron (green) recorded over several minutes. (Right Inset) Ongoing neuropil input signal and an output on expanded time scale.
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Comment on

References

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