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Comparative Study
. 2005 Oct;49(10):4410-2.
doi: 10.1128/AAC.49.10.4410-4412.2005.

Inhibition of class D beta-lactamases by acyl phosphates and phosphonates

S A Adediran  1 , Michiyoshi Nukaga, Stéphane Baurin, J-M Frère, R F Pratt
Affiliations
Comparative Study

Inhibition of class D beta-lactamases by acyl phosphates and phosphonates

S A Adediran et al. Antimicrob Agents Chemother. 2005 Oct.

Abstract

The susceptibility of typical class D beta-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM beta-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.

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Figures

FIG. 1.
FIG. 1.
Structures of phosph(on)ates 1 to 9.
See this image and copyright information in PMC

References

    1. Barlow, M., and B. G. Hall. 2002. Phylogenetic analysis shows that the OXA beta-lactamase genes have been on plasmids for millions of years. J. Mol. Evol. 55:314-327. - PubMed
    1. Bush, K., G. A. Jacoby, and A. A. Medeiros. 1995. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:1211-1233. - PMC - PubMed
    1. Golemi, D., L. Maveyraud, S. Vakulenko, J.-P. Samama, and S. Mobashery. 2001. Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases. Proc. Natl. Acad. Sci. USA 98:14280-14285. - PMC - PubMed
    1. Kaur, K., S. A. Adediran, M. J. K. Lan, and R. F. Pratt. 2003. Inhibition of β-lactamases by monocyclic acyl phosph(on)ates. Biochemistry 42:1529-1536. - PubMed
    1. Kaur, K., and R. F. Pratt. 2001. Mechanism of reaction of acyl phosph(on)ates with the β-lactamase of Enterobacter cloacae P99. Biochemistry 40:4610-4621. - PubMed

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