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. 2005 Oct 5;127(39):13448-9.
doi: 10.1021/ja052188y.

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery

Huiguang Zhu  1 , Michael J McShane
Affiliations

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery

Huiguang Zhu et al. J Am Chem Soc. .

Abstract

A straightforward method for loading hydrophobic materials into commercially available polymer nano- or microparticles is described. PMMA and PS nano/microparticles were swelled by an organic solvent with an ionic surfactant (SDS) to stabilize the particles in aqueous solution. FITC and Ru(dpp)3Cl2 were loaded into those particles based on the principle of "like dissolves like". Further surface modification of the loaded particles was achieved via layer-by-layer (LbL) self-assembly. Culture of fibroblasts with the dye-doped, coated particles showed that the cells internalized the fluorescent particles with no apparent toxic effects. The findings suggest the facile process could be useful in a wide range of applications for fluorescent micro/nanosensors and drug delivery.

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Figures

Figure 1
Figure 1
Confocal microscope images of 1 μm PMMA particles with loaded (A) Ru(dpp)3Cl2 and (B) FITC.
Figure 2
Figure 2
Emission spectrum of Ru(dpp) in different media: (A) EtOH, (B) DI water, (C) within PMMA particles in DI water, (D) within PMMA particles purged with O2, and (E) within PMMA particles, purged with N2.
Figure 3
Figure 3
Confocal microscope images of 3T3 fibroblasts with Ru(dpp)3-loaded PMMA particles (a) with and (b) without {PAH/PSS}3 coating.
Scheme 1
Scheme 1. Loading of Hydrophobic Material into Polymer Particles
See this image and copyright information in PMC

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