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. 2005 Oct 5;127(39):13510-1.
doi: 10.1021/ja0542688.

Catalytic decarboxylative sp-sp3 coupling

Dinesh Kumar Rayabarapu  1 , Jon A Tunge
Affiliations

Catalytic decarboxylative sp-sp3 coupling

Dinesh Kumar Rayabarapu et al. J Am Chem Soc. .

Abstract

A palladium-catalyzed 1,4-enyne synthesis was developed based the decarboxylative coupling of acetylides with allyl electrophiles. Stereochemical studies have implicated palladium-allyl-acetylides as intermediates. Thus, decarboxylative metalation was established as an environmentally benign alternative to transmetalation from alkynyl tin reagents.

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