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Case Reports
. 2005 Aug;15(4):703-5.
doi: 10.1089/cap.2005.15.703.

Successful desensitization of methylphenidate-induced rash

Ronit Confino-Cohen  1 , Arnon Goldberg
Affiliations
Case Reports

Successful desensitization of methylphenidate-induced rash

Ronit Confino-Cohen et al. J Child Adolesc Psychopharmacol. 2005 Aug.

Abstract

Objective: Methylphenidate is a cornerstone of attention-deficit/hyperactivity disorder (ADHD) treatment. Cutaneous adverse reactions resulting from methylphenidate may prohibit its usage. We sought a way to continue this therapy in a patient who developed a rash twice following methylphenidate administration.

Methods: In a desensitization protocol, methylphenidate was given in increasing doses, 30 minutes apart, over 10 days, until the therapeutic dose was reached and was continued regularly thereafter.

Results: No adverse reactions developed during the desensitization period or during the 6- month follow-up.

Conclusions: In nonlife threatening cutaneous adverse reactions to methylphenidate, a desensitization protocol may enable the continued, safe administration of this drug.

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Comment in

  • OROS methylphenidate-induced skin eruptions.
    Coskun M, Tutkunkardas MD, Zoroglu S. Coskun M, et al. J Child Adolesc Psychopharmacol. 2009 Oct;19(5):593-4. doi: 10.1089/cap.2009.0009. J Child Adolesc Psychopharmacol. 2009. PMID: 19877987 No abstract available.

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