Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Oct;59(5):595-8.
doi: 10.1111/j.1440-1819.2005.01420.x.

Linkage disequilibrium in aquaporin 4 gene and association study with schizophrenia

Tatsuyuki Muratake  1 , Naoki Fukui, Naoshi Kaneko, Hideki Amagane, Toshiyuki Someya
Affiliations
Free article

Linkage disequilibrium in aquaporin 4 gene and association study with schizophrenia

Tatsuyuki Muratake et al. Psychiatry Clin Neurosci. 2005 Oct.
Free article

Abstract

Aquaporin 4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity. Several genome scan studies for schizophrenia found a suggestive linkage on 18q, where human AQP4 (18q11.2-12.1) is located nearby. A case-control study was performed which comprised 261 schizophrenia subjects and 278 controls from the Japanese population with four SNP markers. We found strong linkage disequilibrium (LD) and an LD block in the AQP4 gene but found no association between AQP4 and schizophrenia, both single SNP and haplotype analyses. The present study shows that AQP4 is not directly associated with schizophrenia in these Japanese patients.

PubMed Disclaimer