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. 2005 Oct 12;127(40):13760-1.
doi: 10.1021/ja053946n.

Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex

Ryo Takita  1 , Kenichiro Yakura, Takashi Ohshima, Masakatsu Shibasaki
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Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex

Ryo Takita et al. J Am Chem Soc. .

Abstract

Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the "bifunctional character" of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to >99% ee).

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