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. 2005 Oct 12;127(40):13784-5.
doi: 10.1021/ja054500+.

The alpha-helix folds more rapidly at the C-terminus than at the N-terminus

Angela Pozo Ramajo  1 , Sarah A Petty, Agnieszka Starzyk, Sean M Decatur, Martin Volk
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The alpha-helix folds more rapidly at the C-terminus than at the N-terminus

Angela Pozo Ramajo et al. J Am Chem Soc. .

Abstract

The helix-coil dynamics of different sections of an alpha-helical model peptide were observed separately by nanosecond temperature jump experiments with IR detection on a series of isotopically labeled peptides. The results show that the helix-coil dynamics of the alpha-helical C-terminus are faster than those of the N-terminus.

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