Review
doi: 10.1515/BC.2005.084.
Splicing of a rare class of introns by the U12-dependent spliceosome
Affiliations
- PMID: 16201866
- DOI: 10.1515/BC.2005.084
Item in Clipboard
Review
Splicing of a rare class of introns by the U12-dependent spliceosome
Biol Chem.
2005 Aug.
Abstract
Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.
Similar articles
-
RS domain-splicing signal interactions in splicing of U12-type and U2-type introns.Nat Struct Mol Biol. 2007 Jul;14(7):597-603. doi: 10.1038/nsmb1263. Epub 2007 Jul 1. Nat Struct Mol Biol. 2007. PMID: 17603499
-
Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly.Mol Cell Biol. 2005 Jun;25(12):4813-25. doi: 10.1128/MCB.25.12.4813-4825.2005. Mol Cell Biol. 2005. PMID: 15923601 Free PMC article.
-
U12DB: a database of orthologous U12-type spliceosomal introns.Nucleic Acids Res. 2007 Jan;35(Database issue):D110-5. doi: 10.1093/nar/gkl796. Epub 2006 Nov 1. Nucleic Acids Res. 2007. PMID: 17082203 Free PMC article.
-
Towards understanding the catalytic core structure of the spliceosome.Biochem Soc Trans. 2005 Jun;33(Pt 3):447-9. doi: 10.1042/BST0330447. Biochem Soc Trans. 2005. PMID: 15916538 Review.
-
Splicing double: insights from the second spliceosome.Nat Rev Mol Cell Biol. 2003 Dec;4(12):960-70. doi: 10.1038/nrm1259. Nat Rev Mol Cell Biol. 2003. PMID: 14685174 Review. No abstract available.
Cited by
-
Improved identification of enriched peptide RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry.Nucleic Acids Res. 2007;35(15):e95. doi: 10.1093/nar/gkm540. Epub 2007 Jul 25. Nucleic Acids Res. 2007. PMID: 17652325 Free PMC article.
-
Alternative Splicing in Human Biology and Disease.Methods Mol Biol. 2022;2537:1-19. doi: 10.1007/978-1-0716-2521-7_1. Methods Mol Biol. 2022. PMID: 35895255
-
Targeting Viral Transcription for HIV Cure Strategies.Microorganisms. 2024 Apr 8;12(4):752. doi: 10.3390/microorganisms12040752. Microorganisms. 2024. PMID: 38674696 Free PMC article. Review.
-
Transcriptome-wide outlier approach identifies individuals with minor spliceopathies.medRxiv [Preprint]. 2025 Jan 3:2025.01.02.24318941. doi: 10.1101/2025.01.02.24318941. medRxiv. 2025. PMID: 39802771 Free PMC article. Preprint.
-
Pick one, but be quick: 5' splice sites and the problems of too many choices.Genes Dev. 2013 Jan 15;27(2):129-44. doi: 10.1101/gad.209759.112. Genes Dev. 2013. PMID: 23348838 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
