Heparin-induced thrombocytopenia: an update

doi:10.1186/1477-9560-3-14

. 2005 Oct 4:3:14.

doi: 10.1186/1477-9560-3-14.

Heparin-induced thrombocytopenia: an update

Massimo Franchini¹

Affiliations

PMID: 16202170
PMCID: PMC1262784
DOI: 10.1186/1477-9560-3-14

Heparin-induced thrombocytopenia: an update

Massimo Franchini. Thromb J. 2005.

. 2005 Oct 4:3:14.

doi: 10.1186/1477-9560-3-14.

Author

Massimo Franchini¹

Affiliation

¹ Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@univr.it

PMID: 16202170
PMCID: PMC1262784
DOI: 10.1186/1477-9560-3-14

Abstract

Heparin-induced thrombocytopenia (HIT) is the most important and most frequent drug-induced, immune-mediated type of thrombocytopenia. It is associated with significant morbidity and mortality if unrecognized. In this review, we briefly discuss the main features of heparin-induced thrombocytopenia, particularly analyzing the most recent advances in the pathophysiology, diagnosis and treatment of this syndrome.

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Figures

**Figure 1**
Pathophysiology of heparin induced thrombocytopenia.

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References

1. Chong BH. Heparin-induced thrombocytopenia. J Thromb Haemost. 2003;1:1471–1478. doi: 10.1046/j.1538-7836.2003.00270.x. - DOI - PubMed
1. Jang I-K, Hursting HJ. When heparins promote thrombosis. Review of heparin-induced thrombocytopenia. Circulation. 2005;111:2671–2683. doi: 10.1161/CIRCULATIONAHA.104.518563. - DOI - PubMed
1. Warkentin TE. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol. 2003;121:535–555. doi: 10.1046/j.1365-2141.2003.04334.x. - DOI - PubMed
1. Warkentin TE. Heparin-induced thrombocytopenia. Diagnosis and management. Circulation. 2004;110:e454–458. doi: 10.1161/01.CIR.0000147537.72829.1B. - DOI - PubMed
1. Cines DB, Bussel JB, McMillan RB, Zehnder JL. Congenital and acquired thrombocytopenia. Hematology (Am Soc Hematol Educ Program) 2004:390–406. - PubMed

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[1] Chong BH. Heparin-induced thrombocytopenia. J Thromb Haemost. 2003;1:1471–1478. doi: 10.1046/j.1538-7836.2003.00270.x. - DOI - PubMed

[2] Chong BH. Heparin-induced thrombocytopenia. J Thromb Haemost. 2003;1:1471–1478. doi: 10.1046/j.1538-7836.2003.00270.x. - DOI - PubMed

[3] Jang I-K, Hursting HJ. When heparins promote thrombosis. Review of heparin-induced thrombocytopenia. Circulation. 2005;111:2671–2683. doi: 10.1161/CIRCULATIONAHA.104.518563. - DOI - PubMed

[4] Jang I-K, Hursting HJ. When heparins promote thrombosis. Review of heparin-induced thrombocytopenia. Circulation. 2005;111:2671–2683. doi: 10.1161/CIRCULATIONAHA.104.518563. - DOI - PubMed

[5] Warkentin TE. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol. 2003;121:535–555. doi: 10.1046/j.1365-2141.2003.04334.x. - DOI - PubMed

[6] Warkentin TE. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol. 2003;121:535–555. doi: 10.1046/j.1365-2141.2003.04334.x. - DOI - PubMed

[7] Warkentin TE. Heparin-induced thrombocytopenia. Diagnosis and management. Circulation. 2004;110:e454–458. doi: 10.1161/01.CIR.0000147537.72829.1B. - DOI - PubMed

[8] Warkentin TE. Heparin-induced thrombocytopenia. Diagnosis and management. Circulation. 2004;110:e454–458. doi: 10.1161/01.CIR.0000147537.72829.1B. - DOI - PubMed

[9] Cines DB, Bussel JB, McMillan RB, Zehnder JL. Congenital and acquired thrombocytopenia. Hematology (Am Soc Hematol Educ Program) 2004:390–406. - PubMed

[10] Cines DB, Bussel JB, McMillan RB, Zehnder JL. Congenital and acquired thrombocytopenia. Hematology (Am Soc Hematol Educ Program) 2004:390–406. - PubMed

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Heparin-induced thrombocytopenia: an update

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