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Review
. 2005 Jul-Sep;9(3):569-82.
doi: 10.1111/j.1582-4934.2005.tb00489.x.

The molecular basis of transdifferentiation

Wan-Chun Li  1 , Wei-Yuan Yu, Jonathan M Quinlan, Zoë D Burke, David Tosh
Affiliations
Review

The molecular basis of transdifferentiation

Wan-Chun Li et al. J Cell Mol Med. 2005 Jul-Sep.

Abstract

There is now excellent experimental evidence demonstrating the remarkable ability of some differentiated cells to convert to a completely different phenotype. The conversion of one cellular phenotype to another is referred to as 'transdifferentiation' and belongs to a wider class of cell-type switches termed 'metaplasias'. Defining the molecular steps in transdifferentiation will help us to understand the developmental biology of the cells that interconvert, as well as help identify key regulatory transcription factors that may be important for the reprogramming of stem cells. Ultimately, being able to produce cells at will offers a compelling new approach to therapeutic transplantation and therefore the treatment and cure of diseases such as diabetes.

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References

    1. Tosh D, Slack JMW. How cells change their phenotype. Nat Rev Mol Cell Biol. 2002; 3: 187–94. - PubMed
    1. Beresford WA. Direct transdifferentiation: can cells change their phenotype without dividing Cell Differ Dev. 1990; 29: 81–93. - PubMed
    1. Slack JMW, Tosh D. Transdifferentiation and metaplasia ‐ switching cell types. Curr Opin Genet Dev. 2001; 11: 581–6. - PubMed
    1. Taylor SM, Jones PA. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5‐azacytidine. Cell 1979; 17: 771–9. - PubMed
    1. Konieczny SF, Emerson CP Jr. 5‐Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination, Cell 1984; 38: 791–800. - PubMed

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