Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec 1;15(23):5211-7.
doi: 10.1016/j.bmcl.2005.08.100. Epub 2005 Oct 3.

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Ning Xi  1 , Yunxin Bo, Elizabeth M Doherty, Christopher Fotsch, Narender R Gavva, Nianhe Han, Randall W Hungate, Lana Klionsky, Qingyian Liu, Rami Tamir, Shimin Xu, James J S Treanor, Mark H Norman
Affiliations

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Ning Xi et al. Bioorg Med Chem Lett. .

Abstract

A thiazole derivative, 2-(2,6-dichlorobenzyl)-N-(4-isopropylphenyl) thiazole-4-carboxamide (1), was identified as a TRPV1 antagonist. We synthesized various thiazole analogs and evaluated them for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. The IC(50) values of the most potent antagonists were ca. 0.050microM in these assays.

PubMed Disclaimer

LinkOut - more resources