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. 2005 Dec 1;15(23):5311-4.
doi: 10.1016/j.bmcl.2005.08.072. Epub 2005 Oct 3.

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

Zhijian Lu  1 , Joann Bohn, Tom Rano, Carrie A Rutkowski, Amy L Simcoe, David B Olsen, William A Schleif, Anthony Carella, Lori Gabryelski, Lixia Jin, Jiunn H Lin, Emilio Emini, Kevin Chapman, James R Tata
Affiliations

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

Zhijian Lu et al. Bioorg Med Chem Lett. .

Abstract

Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biology are described.

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