Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Oct;43(10):5275-7.
doi: 10.1128/JCM.43.10.5275-5277.2005.

Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead

Leonardo A Sechi  1 , Maria Gazouli, John Ikonomopoulos, John C Lukas, Antonio M Scanu, Niyaz Ahmed, Giovanni Fadda, Stefania Zanetti
Affiliations

Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead

Leonardo A Sechi et al. J Clin Microbiol. 2005 Oct.

Abstract

The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod 2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD 2/CARD 15 gene (ins C 3020, G 908 R, and R 702 W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD 2/CARD 15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Behr, M. A., M. Semret, A. Poon, and E. Schurr. 2004. Crohn's disease, mycobacteria, and NOD2. Lancet Infect. Dis. 4:136-137. - PubMed
    1. Gazouli, M., P. Zacharatos, G. J. Mantzaris, C. Barbatis, I. Ikonomopoulos, A. J. Archimandritis, J. C. Lukas, E. Papalambros, and V. Gorgoulis. 2004. Association of NOD2/CARD15 variants with Crohn's disease in a Greek population. Eur. J. Gastroenterol. Hepatol. 16:1177-1182. - PubMed
    1. Hampe, J., A. Cuthbert, P. J. Croucher, M. M. Mirza, S. Mascheretti, S. Fisher, H. Frenzel, K. King, A. Hasselmeyer, A. J. MacPherson, S. Bridger, S. van Deventer, A. Forbes, S. Nikolaus, J. E. Lennard-Jones, U. R. Foelsch, M. Krawczak, C. Lewis, S. Schreiber, and C. G. Mathew. 2001. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 16:1925-1928. - PubMed
    1. Hugot, J. P., M. Chamaillard, H. Zouali, S. Lesage, J. P. Cezard, J. Belaiche, S. Almer, C. Tysk, C. A. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J. F. Colombel, M. Sahbatou, and G. Thomas. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603. - PubMed
    1. Inohara, N., Y. Ogura, A. Fontalba, O. Gutierrez, F. Pons, J. Crespo, K. Fukase, S. Inamura, S. Kusumoto, M. Hashimoto, S. J. Foster, A. P Moran, J. L. Fernandez-Luna, and G. Nunez. 2003. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278:5509-5512. - PubMed

Publication types

MeSH terms

Substances