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Case Reports
. 2005 Jan;9(1):6-9.
doi: 10.1007/s10227-005-0024-4.

Combined Merkel cell carcinoma and atypical fibroxanthoma

Summer R Youker  1 , Elizabeth M Billingsley
Affiliations
Case Reports

Combined Merkel cell carcinoma and atypical fibroxanthoma

Summer R Youker et al. J Cutan Med Surg. 2005 Jan.

Abstract

Background: Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atypical fibroxanthoma occurring in conjunction with a Merkel cell carcinoma.

Objective: We report on a neoplasm with distinct features of both Merkel cell carcinoma and atypical fibroxanthoma.

Methods: Histologic and immunohistochemical evaluations were performed.

Results: Our results verify the finding of a combined Merkel cell carcinoma and atypical fibroxanthoma.

Conclusion: This case is an interesting and unusual combination of tumors. The origin of the Merkel cell carcinoma is revisited. Debated origins include neuroendocrine, epithelial, and pleuripotent stem cell.

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