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Review
. 2005 Oct 8;331(7520):836-8.
doi: 10.1136/bmj.331.7520.836.

How well does the evidence on pioglitazone back up researchers' claims for a reduction in macrovascular events?

Nick Freemantle  1
Affiliations
Review

How well does the evidence on pioglitazone back up researchers' claims for a reduction in macrovascular events?

Nick Freemantle. BMJ. .

Abstract

Recent claims that pioglitazone prevents macrovascular events are based on a secondary outcome measure. But ignoring the primary outcome is statistically unsound

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Figures

Figure 1
Figure 1
Oral glucose lowering drugs may prevent patients needing insulin injections but the evidence on macrovascular events is still questionable Credit: IAN HOOTON/SPL
See this image and copyright information in PMC

Comment in

References

    1. Official PROactive results website www.proactive-results.com/index.htm (accessed 15 Sep 2005).
    1. Freemantle N. Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic? BMJ 2001;322: 989-91. - PMC - PubMed
    1. Fisher LD. Carvedilol and the Food and Drug Administration (FDA) approval process: the FDA paradigm and reflections on hypothesis testing. Controlled Clin Trials 1999;20: 16-39. - PubMed
    1. Freemantle N, Calvert M, Wood J, Eastaugh J, Griffin C. Composite outcomes in randomized trials: greater precision but with greater uncertainty? JAMA 2003;289: 2554-9. - PubMed

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