doi: 10.1016/j.bmcl.2005.04.079.
Epub 2005 Oct 4.
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
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- PMID: 16213138
- DOI: 10.1016/j.bmcl.2005.04.079
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Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Bioorg Med Chem Lett.
.
Abstract
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
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