Review
doi: 10.1016/j.cell.2005.09.017.
The blood-brain barrier--lessons from moody flies
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- PMID: 16213208
- DOI: 10.1016/j.cell.2005.09.017
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Review
The blood-brain barrier--lessons from moody flies
Cell.
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Abstract
Despite the importance of the blood-brain barrier (BBB), little is known about the molecular mechanisms that control its integrity. The identification of moody, a gene required for the formation and maintenance of the Drosophila BBB, provides new insight into how paracellular junctions are formed at the barrier. Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics.
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